It’s hit or miss. Really depends on the software requirements, versions of wine, your system in general, etc.
For example; I used the streamer.bot Linux install script to successfully install a new wine prefix that runs the app great. This requires dotnet48 and other dotnet dependencies. But it only worked after several failed attempts because I had to downgrade wine to 9.0 from 9.1 on Debian 12. I’ve since moved to arch and no matter what version of wine I’m running, the program will not work anymore even as fresh install. I’ve yet to fully diagnose what’s wrong.
For me, even on X11, it’s hit or miss if the copy actually makes it to the clipboard. I’d say 50:50 I can paste the image or I have to clip again.